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A unified catalog of 204,938 reference genomes from the human…
Comprehensive, high-quality reference genomes are required for functional characterization and taxonomic assignment of the human gut microbiota. We present the Unified Human Gastrointestinal Genome (UHGG) collection, comprising 204,938…
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OME-Zarr: a cloud-optimized bioimaging file format with…
A growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by
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Continental Industry | Continental Industry
Před 2 měsíciCompanies have the power to lead the transition to a sustainable future. But as Caring Explorers we already know it takes time, ideas, and patience to create the right solutions for each individual business. One important step in this…
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The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut…
The gut microbiota is emerging as a promising target for the management or prevention of inflammatory and metabolic disorders in humans. Many of the current research efforts are focused on the identification of specific microbial signatures…
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Conformational control of DNA target cleavage by Crispr–Cas9…
Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destruction as part of a bacterial adaptive immune system mediated by Crispr (clustered regularly interspaced short palindromic repeats)1,2.
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Frontiers | Ciphers and Executioners: How 3′-Untranslated…
The sequences and structures of 3’-untranslated regions (3’UTRs) of messenger RNAs govern their stability, localization, and expression. 3’UTRs regulatory el...
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Helicase - Wikipedia
Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis.
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Long-read sequencing technology indicates genome-wide effects…
DNA conformation may deviate from the classical B-form in ∼13% of the human genome. Non-B DNA regulates many cellular processes; however, its effects on DNA polymerization speed and accuracy have not been investigated genome-wide.
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The MetaCyc database of metabolic pathways and enzymes and the…
The MetaCyc database (MetaCyc.org) is a freely accessible comprehensive database describing metabolic pathways and enzymes from all domains of life. The majority of MetaCyc pathways are small-molecule metabolic pathways that have been…
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