Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a prevalence of 10 to 25% in the United States and has a high disease burden, as…
When a microbe such as a virus, bacterium, fungus, protozoan or archaeon has been linked to a disease, researchers may start to investigate whether that microbe might be the underlying cause of the disease, or might play a causal role in…
The complex role of the gut microbiome in the pathogenesis of gastrointestinal (GI) disorders is an emerging area of research, and there is considerable interest in understanding how diet can alter the composition and function of the…
Low-frequency variants are enriched for potentially functional mutations, for example protein-changing variants, under weak purifying selection1,5,6. Furthermore, low-frequency variants, because they tend to be recent in origin, exhibit…
Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which is often accompanied by gastrointestinal symptoms. Experiments have demonstrated that the disorder of the intestinal microbial system…