CD8α+ dendritic cells (DCs) prime cytotoxic T lymphocytes during viral infections and produce interleukin-12 in response to pathogens. Although the loss of CD8α+ DCs in Batf3−/− mice increases their susceptibility to several pathogens, we…
A large body of experimental and observational data has implicated vitamin D deficiency in the development of cardiovascular disease. However, evidence to support routine vitamin D supplementation to prevent or treat cardiovascular disease…
Equol [7-hydroxy-3-(4′-hydroxyphenyl)-chroman], an isoflavan produced by intestinal bacteria in response to soy isoflavone intake in some but not all humans, exhibits a wide range of biological properties.
Disorders of sex development (DSDs), also known as differences in sex development, variations in sex characteristics (VSC), [2 ] [3 ] sexual anomalies, or sexual abnormalities, are congenital conditions affecting the reproductive system, in…
The wide variety of dissemination and implementation designs now being used to evaluate and improve health systems and outcomes warrants review of the scope, features, and limitations of these designs.
Elaine H. Zackai, MD, is the Senior Clinical Geneticist at Children's Hospital of Philadelphia. She holds the Endowed Chair in Clinical Genetics in the Department of Pediatrics and is a Professor, Division of Human Genetics, Department of…