The α4β7 integrin promotes homing of T cells to intestinal sites. The α4 integrin subunit that pairs with β7 integrin can also pair with β1 integrin. Here, we show that the preferential pairing of β1 integrin with α4 integrin regulates the…
Cryo-electron microscopy (cryo-EM) is increasingly becoming a mainstream technology for studying the architecture of cells, viruses and protein assemblies at molecular resolution. Recent developments in microscope design and imaging…
Cytochrome P450 3A4 (CYP3A4) metabolizes ~50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of genetic factors remains uncertain.
En biología y citogenética, se denomina cromosoma [a ] (del griego χρώμα, -τος chroma, color y σώμα, -τος soma, cuerpo o elemento) a cada una de las estructuras altamente organizadas, formadas por ADN y proteínas, que contiene la mayor…
Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood.
Su base institucional es extremadamente débil y está en continuo declive. Sin embargo, hay cierta preocupación entre sus hablantes, que tienen una conexión emocional con la lengua y su relación con la identidad sarda.