E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis.
Inflammation is associated with oxidative stress and local generation of lipid peroxidation-derived aldehydes, such as 4-hydroxy-trans-2-nonenal (HNE). In most tissues, HNE is readily conjugated with glutathione and presently it is unknown…
Bengt Fadeel, MD, PhD, is a Professor of Medical Inflammation Research.He is also the Vice Chairman of the Institute of Environmental Medicine.Prof. Fadeel is a Fellow of the Academy of Toxicological Sciences (ATS) and Member of Academia…
While Parkinson’s disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes.
Inappropriate or excessive pulmonary inflammation can contribute to chronic lung diseases. In health, the resolution of inflammation is an active process that terminates inflammatory responses.
Resolution of inflammation has historically been viewed as a passive process, occurring as a result of the withdrawal of pro-inflammatory signals, including lipid mediators such as leukotrienes and prostaglandins.
Juha Kere (born 1958) is professor of molecular genetics at KI since 2001. He graduated with MD (1984), PhD in molecular genetics (1989) and specialist physician degree in clinical genetics (1994) from University of Helsinki.