ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen…
We showed previously in neocortical explants, derived from developing wild-type and estrogen receptor (ER)-α gene-disrupted (ERKO) mice, that both 17α- and 17β-estradiol elicit the rapid and sustained phosphorylation and activation of the…
ER-X - Wikipedia
ER-X is a membrane-associated receptor that is bound and activated by 17α-estradiol and 17β-estradiol and is a putative membrane estrogen receptor (mER). [1 ] [2 ] [3 ] It shows sequence homology with ERα and ERβ and activates the MAPK/ERK…
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Mork Goes Erk - Wikipedia
"Mork Goes Erk" is the seventeenth episode of the first season of the American television sitcom Mork & Mindy. The episode aired on ABC on February 8, 1979. [1 ] It was issued on VHS on January 1, 1998, as part of a two-episode special…
Progesterone - Wikipedia
Progesterone (/ p r oʊ ˈ dʒ ɛ s t ər oʊ n/ ; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. [1 ] [13 ] It belongs to a group of steroid…
ncb1233.pdf
These ERK dynamics depend on Ras and Rap1 dynamics, the inactivation processes of which are growth-factor- dependent and -independent, respectively.
SARS-CoV-2 Spike Protein and Its Receptor Binding Domain…
Dendritic cells (DCs) are the most potent antigen-presenting cells, and their function is essential to configure adaptative immunity and avoid excessive inflammation. DCs are predicted to play a crucial role in the clinical evolution of the…
Extracellular Signal-Regulated Kinase (ERK) Controls Immediate…
Activity-dependent changes in neuronal structure and synaptic remodeling depend critically on gene regulation. In an attempt to understand how glutamate receptor stimulation at the membrane leads to gene regulation in the nucleus, we traced…
Mechanism of short-term ERK activation by electromagnetic…
The exposure to non-thermal microwave electromagnetic fields generated by mobile phones affects the expression of many proteins. This effect on transcription and protein stability can be mediated by the MAPK (mitogen-activated protein…
Steroid Glycosides Hyrcanoside and Deglucohyrcanoside: On…
Cardiac glycosides (CGs) represent a group of sundry compounds of natural origin. Most CGs are potent inhibitors of Na+/K+-ATPase, and some are routinely utilized in the treatment of various cardiac conditions.
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2…
The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that ERK downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and phosphorylating FOXO3a at Ser 294…
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