The S3 language that was used to write the ICL VME operating system and much other system software on the ICL 2900 Series was a direct derivative of Algol 68.
The new AlphaFold model demonstrates greatly improved accuracy over previous specialist tools in the majority of cases: far greater accuracy on protein-ligand interactions than state of the art docking tools, much higher accuracy on protein…
Background: BTB-Kelch proteins, including KLHL11, are proposed to bind Cul3 through a “3-box” motif to form E3 ubiquitin ligases. Results: We solved crystal structures of the KLHL11-Cul3 complex and four Kelch domains.
Most BTB-containing E3 ligases homodimerize to recognize a single substrate by engaging multiple degrons, represented by E3 ligase KEAP1 dimer and its substrate NRF2. Inactivating KEAP1 to hinder ubiquitination-dependent NRF2 degradation…