Ramipril, sold under the brand name Altace among others, is an ACE inhibitor type medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [1 ] It can also be used as a preventative medication in patients…
The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor suppressive mechanism of cellular senescence, causing a striking absence of stratified epithelia such…
Hematopoietic malignancies are frequently associated with DNA hypomethylation but the molecular mechanisms involved in tumor formation remain poorly understood. Here we report that mice lacking Lsh develop leukemia associated with DNA
Synthetic suburethral slings have become the most widely used technique for the surgical treatment of stress urinary incontinence. Despite its high success rates, significant complications have been reported including bleeding, urethral or…
Chronic, low-grade inflammation, particularly in adipose tissue, is an important modulator of obesity-induced insulin resistance and the toll-like receptor 4 (Tlr4) is a key initiator of inflammatory responses in macrophages.
The main causes of morbidity with the illness are systemic infection from impaired immune response and organ dysfunction from histiocyte deposition throughout the body. [1 ] [4 ]
Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it.
The most in-depth profile of Australian business leaders in generations. The Interview AU is a premium long-form interview series that goes beyond headlines ...
The persistent tradition of a Greek colonization of the Maltese Islands in ancient times was inspired mainly by ancient literary allusions. These are basically: 1) the identification of the Homeric island of Ogygia, Calypso's refuge, with…
What archaeological evidence supports Greek colonization in Malta?The study reveals that archaeological finds, such as a Mycenaean cup dated to c. 1350 B.C., suggest a possible Greek presence. However, Greek ceramics discovered later primarily indicate a Hellenistic influence, postdating the Roman annexation in 218 B.C.How did ancient literary sources contribute to the Greek colonization theory?Literary sources like Lycophron's 'Alexandra' date the alleged Greek settlement to post-Trojan War circa 1250 B.C. Despite their influence, many of these references are viewed as lacking historical credibility.What did Philipp Cluver assert about Greek relationships with Malta?Cluver proposed that relationships with Greek tyrant Phalaris implied a Greek presence in Malta during the sixth century B.C. However, the authenticity of the letters attributed to Phalaris is highly disputed.