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The severity of Covid-19 remains high worldwide. Therefore, millions of individuals are likely to suffer from fear of Covid-19 and related mental health factors. The present systematic review and meta-analysis aimed to synthesize empirical…
Posttraumatic stress disorder (PTSD) is associated with long-term changes in neurobiology. Brain areas involved in the stress response include the medial prefrontal cortex, hippocampus, and amygdala.
Studies in animals showed that stress is associated with changes in hippocampal function and structure, an effect mediated through decreased neurogenesis, increased glucocorticoids, and/or decreased brain derived neurotrophic factor.
There is strong evidence that aging is associated with an increased presence of senescent cells in the brain. The finding that treatment with senolytic drugs improves cognitive performance of aged laboratory mice suggests that increased…
The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium (“KATP”) channel, a…
The immune system plays fundamental roles in maintaining physiological homeostasis. With the increasing prevalence of obesity—a state characterized by chronic inflammation and systemic dyshomeostasis—there is growing scientific and clinical…
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