Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen…
Resveratrol, a polyphenol presents in grapes and wine, displays antioxidant and anti-inflammatory properties and cytoprotective effect in brain pathologies associated to oxidative stress and neurodegeneration.
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Modulation of mitochondrial function by the microbiome…
Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric microbiome. PPA is a normal intermediate of metabolism and is found in foods, either naturally or as a preservative.
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate…
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a single amino acid residue of the IDH1 active site resulting in loss of the…
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L-Carnitine and acetyl-L-carnitine roles and neuroprotection in…
L-Carnitine functions to transport long chain fatty acyl CoAs into the mitochondria for degradation by β-oxidation. Treatment with L-carnitine can ameliorate metabolic imbalance in many inborn errors of metabolism.
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The enteric bacterial metabolite propionic acid alters brain…
Gastrointestinal symptoms and altered blood phospholipid profiles have been reported in patients with autism spectrum disorders (ASD). Most of the phospholipid analyses have been conducted on the fatty acid composition of isolated…
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Frontiers | Homeostatic Control of the Thyroid–Pituitary Axis…
The long-held concept of a proportional negative feedback control between the thyroid and pituitary gland requires reconsideration in the light of more recen...
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Leucinóza (MSUD) - Novorozenecký screening
Tato situace se může opakovat pokaždé, když je organizmus zatížen zvýšeným množstvím rozvětvených aminokyselin (např. při běžném úbytku váhy v novorozeneckém období, při odbourávání tělesných bílkovin dítěte při horečce a hladovění, např.
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Non-Thyroidal Illness in the ICU: A Syndrome with Different…
Background: Critically ill patients typically present with low or low-normal plasma thyroxine, low plasma triiodothyronine (T3), increased plasma reverse T3 (rT3) concentrations, in the absence of
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Frontiers | Thyroid Allostasis–Adaptive Responses of…
The hypothalamus-pituitary-thyroid feedback control is a dynamic, adaptive system. In situations of illness and deprivation of energy representing type 1 all...
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Cytologic hallmarks and differential diagnosis of papillary…
1Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
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