The apical domain contains the binding sites for both GroES and the unfolded protein substrate. The equatorial domain contains the ATP-binding site and most of the oligomeric contacts.
By binding to the serotonin transporter (SERT) it inhibits neuronal reuptake of serotonin and potentiates serotonergic activity in the central nervous system. [21 ] Over time, this leads to a downregulation of pre-synaptic 5-HT1A receptors…
14-3-3ζ is one of 7 members of the 14-3-3 protein family, which is ubiquitously expressed and highly conserved among plants and mammals. [6 ] [7 ] [11 ] [12 ] This protein family is known for regulating signal transduction pathways…
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Heliox is a breathing gas mixture of helium (He) and oxygen (O2). It is used as a medical treatment for patients with difficulty breathing because this mixture generates less resistance than atmospheric air when passing through the airways…
The last three decades have been characterized by an exponential growth in knowledge and advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis requires a vulnerable atrial substrate and that the…
Given the timing of the launch of "My Greatest Mistake," the Ascap boycott, according to O'Brien, stunted the momentum of the song's rise in popularity for 13 recordings that were released before the boycott.