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Virtual issue: ESCRT biology in JBC
jbc.org
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18
cell.com
ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells
journals.asm.org
ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular
journals.asm.org
SEED EN - brq
bricspolicycenter.org
FIGURE 1 | Regulation of the mammalian autophagy. Under low nutrient conditions or starvation, the energy sensor AMPK detects alterations in energy pools (AMP/ATP ratio) inhibiting autophagy repressor mTOR and activating ULK1/2 complex. For phagophore formation, ULK1/2 complex activates the Beclin-1 P13kK-class Ill complex. Additional systems activate (red arrows) or inhibit (blue arrows) the activity and assembly of the complex. The elongation of the isolation membrane requires the participation of two ubiquitin-like conjugation systems. The formation of the Atg12-Atg5-Atg16 complex involves the activity of Atg7 and Atg10. The LC3 requires the participation of Atg4 to hydrolyze LC3 into LC3-|, Atg3 as well as Atg7 for conjugation of LC3-Il to pohosphatidyletanolamine (PE). Phagophore closure is regulated by members of ESCRT, CHMP2A VPS4. In the late steps of maturation and fusion, Dynein participates in the mobilization of autc phagosomes. The fusion of auto phagosomes with lysosomes is mediated by members of the SNARE family. Created by BioRender.com.
academia.edu
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18
cell.com
Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
elifesciences.org
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Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
elifesciences.org
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18
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Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
elifesciences.org
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